In the meta-analysis, ibuprofen at a low dose (<1200 mg) had an odds ratio (OR) comparable to acetaminophen and lower than other NSAIDs. The chart above demonstrates the dose response relationship for the risks (odds ratios) of upper GI bleeding with individual NSAIDs. The main indications were musculoskeletal or back pain (48%), sore throat, the common cold and flu (31%).ĭose-response relationships for the risks (odds ratios) of upper GI bleeding with individual NANSAIDs
#IBUPROFEN SIDE EFFECTS 600 MG CODE#
1,108 general practitioners included 8,677 adults (2,900 aspirin 2,886 ibuprofen 2,888 paracetamol 3 patients had no code label number). * This was a blinded, multicentre study in general practice of up to 7 days of aspirin, acetaminophen (both up to 3 g daily), or ibuprofen (up to 1.2 g daily), administered for common painful conditions, using patient generated data with physician assistance. 1,2*ĪSA = acetylsalicylic acid GI = gastrointestinal OTC = over the counter. Statistical analysis tested for equivalence between ibuprofen and acetaminophen, and for difference with ASA. The primary outcome measure was the number of patients with at least one significant adverse event, defined as an event that was serious, severe or moderate, resulted in a second physician consultation, led to cessation of treatment, or was of missing intensity.
#IBUPROFEN SIDE EFFECTS 600 MG TRIAL#
This large-scale randomized trial comparing nonprescription doses of ASA, acetaminophen, and ibuprofen in 8,677 adults measured rates of significant adverse events related to tolerability. In the PAIN study, which included over 8,500 patients, total GI events (including dyspepsia) and abdominal pain were less frequent with ibuprofen (200 mg) compared to ASA (500 mg) or acetaminophen (500 mg) (all p<0.035). When used as directed for acute pain, OTC ibuprofen is well tolerated 1*
The main indications were musculoskeletal or back pain (48%), sore throat, the common cold and flu (31%). 1,108 general practitioners included 8,677 adults (2,900 ASA 2,886 ibuprofen 2,888 acetaminophen 3 patients had no code label number). * This was a blinded, multicentre study in general practice of up to 7 days of ASA, acetaminophen (both up to 3 g daily) or ibuprofen (up to 1.2 g daily), administered for common painful conditions, using patient generated data with physician assistance. 1,2*ĪSA = acetylsalicylic acid GI = gastrointestinal. Statistical analysis tested for equivalence between ibuprofen and acetaminophen and for difference with ASA.
This large scale randomized trial comparing nonprescription doses of ASA, acetaminophen, and ibuprofen in 8,677 adults measured rates of significant adverse events related to tolerability.
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